Succinic acid 2,2-dimethylhydrazide
Succinic acid 2,2-dimethylhydrazide
CAS: 1596-84-5
Molecular Formula: C6H12N2O3
Succinic acid 2,2-dimethylhydrazide - Names and Identifiers
| Name | Succinic acid 2,2-dimethylhydrazide |
| Synonyms | GA4+7 Daminozide Ferrostatin-1 DaMinozide 0.2 Gibberellin A4+7 Daminozide solution,100ppm succinic 2,2-dimethylhydrazide N-Dimethylamino succinamic acid N-(Dimethylamino)succinamic Acid Succinic acid 2,2-dimethylhydrazide 2,2-dimethylhydrazidkyselinyjantarove 4-(2,2-dimethylhydrazino)-4-oxobutanoate 4-(2,2-diMethylhydrazinyl)-4-oxobutanoic acid 4-(2,2-dimethylhydrazinyl)-4-oxobutanoic acid N'~1~,N'~1~,N'~4~,N'~4~-tetramethylbutanedihydrazide N-(Dimethylamino)succinamic acidButanedioic acid mono(2,2-dimethylhydrazide)B-NineDMASASuccinic acid 2,2-dimethylhydrazide |
| CAS | 1596-84-5 |
| EINECS | 216-485-9 |
| InChI | InChI=1/C6H12N2O3/c1-8(2)7-5(9)3-4-6(10)11/h3-4H2,1-2H3,(H,7,9)(H,10,11)/p-1 |
| InChIKey | NOQGZXFMHARMLW-UHFFFAOYSA-N |
Succinic acid 2,2-dimethylhydrazide - Physico-chemical Properties
| Molecular Formula | C6H12N2O3 |
| Molar Mass | 160.17 |
| Density | 1.2751 (rough estimate) |
| Melting Point | 162-164°C(lit.) |
| Boling Point | 286.06°C (rough estimate) |
| Water Solubility | 100 g/L |
| Solubility | Soluble in DMSO (up to 50 mg/ml), or in Water (up to 20 mg/ml with warming). |
| Appearance | White powder |
| Color | White crystalline |
| Merck | 14,2810 |
| BRN | 1863230 |
| pKa | 5.59±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, strong acids, wetting agents, oils, copper-containing compounds. |
| Refractive Index | 1.4500 (estimate) |
| Physical and Chemical Properties | Pure product is white crystal, microstrip odor. m. P. 154-156 °c. 25 ° C solubility: methanol 5%, acetone 2.5%, water 10%, insoluble in lower aliphatic hydrocarbons. No effect on the chemical properties was seen at room temperature for more than 1 year or at 50 °c for more than 5 months. Easy to decompose in case of acid, slow decomposition in case of alkali. Industrial products are off-white powder, m. P. 145 ℃. |
| Use | Used as a dry fruit growth inhibitor, can inhibit the growth of plants |
Succinic acid 2,2-dimethylhydrazide - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 40 - Limited evidence of a carcinogenic effect |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | UN2811 (toxic solid, organic, n.o.s.) |
| WGK Germany | 2 |
| RTECS | WM9625000 |
| HS Code | 29280000 |
Succinic acid 2,2-dimethylhydrazide - Upstream Downstream Industry
| Raw Materials | Succinic anhydride unsym-Dimethylhydrazine |
Succinic acid 2,2-dimethylhydrazide - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Overview | butyl hydrazide scientific name N-dimethylaminobutyric acid, common name daminoxide. It is a white crystal with a melting point of 154-156 °c. Soluble in acetone, methanol, insoluble in lower hydrocarbons. Obtained from the reaction of succinic anhydride with dimethylhydrazine. |
| mechanism of action | butyrylhydrazide is a plant growth inhibitor, its role is to prevent cell division, inhibit cell elongation, dwarf seedlings, and can improve the drought resistance of peanut, so that many fruit trees in advance flowering, improve the rate of fruit and prevent pre-harvest fruit drop. It inhibits the biosynthesis of indole acetic acid. |
| Application | It has been proved by many years and multi-point experiments that butyrylhydrazine can delay plant growth, inhibit shoot growth, increase the content of chlorophyll in leaves, increase the expansion rate of root tuber and promote the expansion of root tuber. |
| plant growth regulator | butyrylhydrazine is an inhibitor of plant growth regulator, which was successfully developed by rubber company of USA in 1962, its role is to prevent cell division, inhibit cell elongation, dwarf seedlings, and can improve the drought resistance of peanuts, so that many fruit trees flowering in advance, improve the rate of fruit set and prevent pre-harvest fruit drop. After being absorbed by plants, butyrylhydrazine can inhibit the biosynthesis of endogenous gibberellin and the synthesis of endogenous auxin in plants, and its main function is to inhibit the growth of new branches and shorten the length of internodes, increase the leaf thickness and chlorophyll content, prevention and treatment of flower to promote fruit set, induced adventitious root formation, stimulate root growth, improve cold resistance. Butyrhydrazide enters the body through the roots, stems and leaves of plants, and has good internal absorption and conduction properties, which are conducted to the action site along with the nutrient flow, butyryl hydrazine can make the leaf palisade tissue elongation, spongy tissue loosening, increase chlorophyll content, enhance leaf photosynthesis. At the top of the plant can inhibit the apical meristem mitosis. The Internode distance can be shortened in the stem and branch, and the elongation of the branch can be inhibited. Butyryl hydrazide is a plant growth regulator with broad spectrum and applicability. teratogenic effects were suspected in the mid and late eighties of the 20th century, and their use was banned or restricted in some countries. A reassessment was carried out in World Health Organization (WHO), and the product was considered to be the hydrolysis product of butanohydrazide, unsymmetrical dimethylhydrazine (Or Asymmetric dimethyl hydrazine) content of less than 30 mg/kg can be used. However, it is still important to note that the crops that will be harvested in the near future should not be used, and the fruits and other agricultural products that have just been treated with drugs should not be used on vegetables. The above information was edited by Tong Tong. |
| method of use | butyrylhydrazine, also known as bijiu, belongs to low toxicity plant growth regulator, can be used as a dwarf agent, fruit setting agent, rooting agent and preservative, etc. spraying the whole plant with 1000-2000 mg/L medicinal solution once three weeks after Apple flowering can inhibit the growth of new shoots, which is beneficial to fruit setting and promoting fruit coloring; spraying the whole plant with 2000-4000 mg/L solution once 45-60 days before harvest can prevent fruit drop before harvest and prolong storage period. spraying 1000-2000 mg/L medicinal solution once on 6-7 leaves of grape shoots can inhibit the growth of new shoots and promote fruit setting; after harvest with 1000~2000 mg/L solution soaking 3~5 minutes, can prevent the extension of the storage period. The Peach was sprayed with 1000-2000 mg/L medicinal solution once before ripening to increase coloration and promote early ripening. pear two weeks after flowering and three weeks before harvest with 1000~2000 mg/L liquid spray once, can prevent young fruit and fruit drop before harvest. spraying 3000 mg/L medicinal solution once two weeks after potato flowering can inhibit Overground overgrowth and promote tuber enlargement. spraying Cherry with 2000-4000 mg/L medicinal solution once two weeks after flowering can promote coloring, early maturing and uniform fruit. The Peanut was sprayed once with 1000-1500 mg/L liquid medicine during the needling period, which could dwarf the plant and increase the yield. spraying 1000 mg/L medicine solution for 2-3 times after strawberry transplantation can promote fruit setting and increase yield. after transplanting, spray the chrysanthemum with 3000 mg/L solution for 2-3 times to dwarf the plant, Enlarged flowers. ginseng grown for 2-3 years was sprayed with 2000-3000 mg/L medicinal solution once during the growth period to promote the growth of underground part. The rooting of cuttings was promoted by soaking the bases of chrysanthemum, poinsettia, Dianthus caryophyllus, Camellia and grape in 5000-10000 mg/L medicinal solution for 15-20 seconds. |
| note | (1) the crop growth, good water and fertilizer conditions, the use effect is more obvious; Poor growth of crops, use under the condition of thin soil and lack of fertilizer can lead to yield reduction. Butyryl hydrazide has a mild effect, and when the concentration is increased, only the inhibition degree of stem and leaf growth is increased, and there is no killing result. (2) butyryl hydrazine has been widely used as a dwarfing agent, fruit setting agent, rooting agent and preservative in agricultural production. Recently in the United States by animal tests found that this product can cause tumors. For this reason, the United States Environmental Protection Agency decided to disable all food crops. According to this situation, it is suggested that domestic butyrylhydrazine products should not be used in food crops and can be used in ornamental plants, seedlings and other non-edible crops. (3) strict Protection Measure should be adopted, such as avoiding contact between drug solution and skin and eyes, or inhalation of medicine mist, etc., and the storage area should be kept away from food and feed, and children should not be allowed to approach. No specific antidote, symptomatic treatment according to symptoms. (4) The preparation is used as it is. If it turns brown, it cannot be used. (5) can be mixed with a variety of pesticides but not with alkaline substances, oil and copper formulations. |
| analysis method | 1. Product Analysis: Take the Volumetric method with Cresol Red as indicator, with 0.1N sodium hydroxide solution titration. 2. Residue Analysis: The residue was hydrolyzed by boiling in 50% sodium hydroxide solution, dimethylhydrazine was distilled off, and red color appeared by action of Trisodium pentacyanamide ferroate, and Colorimetric determination was carried out at 490 and 600nm. It can also be analyzed by gas chromatography using as internal standard, propionyl 666. In addition, spectrophotometric analysis can be used. |
| degradation metabolism | The Half-Life of butyryl hydrazide in soil is about 21 days. |
| toxicity | Acute Oral LD508400mg/kg in rats and acute percutaneous LD50>1600mg/kg in rabbits. The oral LD50> 85% mg/kg of the preparation of the no tail quail. For rainbow trout lc50360 mg/L(96H), tilefish 650mg/L(96H). |
| Use | plant growth inhibitor. Promote dwarfing, and can adjust the trunk height and ornamental plant shape, without affecting the impact of flowering. It has the effect of increasing the ability of cold tolerance and drought tolerance, promoting the effect of grain filling and increasing yield. The mechanism is the inhibition of endogenous auxin synthesis. Can be used for fruit trees, potato, sweet potato, tomato, strawberry, chrysanthemum, ginseng, etc. The National Ministry of Agriculture has withdrawn the registration on peanuts. butyryl hydrazine can inhibit plant growth and promote short growth without affecting flowering and fruiting. It has the effects of increasing cold tolerance and drought tolerance, preventing flower and fruit dropping, promoting grain filling and increasing yield. as an inhibitor of the growth of dry fruit trees, it can inhibit the growth of plants. Bijiu is a kind of growth inhibitor. It can inhibit the biosynthesis of endogenous gibberellin, and can also inhibit the synthesis of endogenous auxin. |
| production method | succinic acid is used as raw material, and succinic anhydride is obtained by dehydration, it is obtained by condensation with unsymmetrical dimethylhydrazine in acetonitrile. The operation steps are: the succinic acid is put into the reaction kettle once, the temperature is raised to about 215 ℃, and the dehydration is started until the temperature rise of the kettle reaches about 260 ℃, and the water output reaches the theoretical amount. Acetonitrile was added to the condensation vessel, and then succinic anhydride was added thereto. When the material temperature was controlled at 18 ° C., unsymmetrical dimethylhydrazine was slowly added dropwise. |
| category | pesticide |
| toxicity grade | low toxicity |
| Acute toxicity | oral-rat LD50: 8400 mg/kg; Oral-mouse LD50: 6300 mg/kg |
| flammability hazard characteristics | toxic NOx gases from combustion |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored and transported separately from food raw materials |
| extinguishing agent | dry powder, foam, sand |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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Raw Materials for Succinic acid 2,2-dimethylhydrazide